Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 3.341


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene



Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_116099648 9.956 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_-_135083906 7.486 NM_205855
FAM180A
family with sequence similarity 180, member A
chr16_+_56219802 7.242 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr19_-_40711034 6.927 NM_001166034
NM_001166035
NM_198538
SBSN


suprabasin


chr5_+_150000394 6.654 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_17719405 6.641 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr1_+_181421984 6.369 LAMC2
laminin, gamma 2
chr6_+_31190505 6.122 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr2_+_169634330 5.593 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr1_-_94779727 5.461 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_-_138470160 5.388 NM_022121
PERP
PERP, TP53 apoptosis effector
chr12_-_68369322 5.347 NM_152439
BEST3
bestrophin 3
chr1_+_245646080 5.143 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr4_+_154397975 4.874 TRIM2
tripartite motif containing 2
chr17_-_36469869 4.744 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr17_-_37022465 4.685 NM_005557
KRT16
keratin 16
chr4_+_169989680 4.610 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr5_+_140848905 4.496 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr4_+_120276386 4.408 NM_016599
MYOZ2
myozenin 2
chr4_+_108965167 4.284 NM_001136258
SGMS2
sphingomyelin synthase 2
chr11_-_101906640 4.280 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr1_+_181421796 4.276 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_181422016 4.188 LAMC2
laminin, gamma 2
chr16_+_70117523 4.103 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr19_-_60573552 4.101 NM_000641
IL11
interleukin 11
chr17_-_7962531 4.057 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr17_+_75776193 4.028 NM_052819
CARD14
caspase recruitment domain family, member 14
chr13_-_35327798 4.010 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr1_+_221955876 3.986 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr2_+_202379442 3.983 NM_139158
CDK15
cyclin-dependent kinase 15
chr6_+_47732181 3.973 NM_153839
GPR111
G protein-coupled receptor 111
chr8_-_38505331 3.804 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr1_+_12698704 3.708 NM_001103169
NM_001103170
AADACL3

arylacetamide deacetylase-like 3

chr11_+_72660894 3.616 NM_004154
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr9_-_90456824 3.568 NM_001100111
LOC286238
hypothetical protein LOC286238
chr1_+_34997928 3.554 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr3_+_11153778 3.481 NM_001098213
HRH1
histamine receptor H1
chr12_-_51173238 3.434 NM_005554
KRT6A
keratin 6A
chr6_-_169392771 3.299


chr4_+_76700281 3.263 NM_178497
C4orf26
chromosome 4 open reading frame 26
chr10_-_21847126 3.252


chr12_-_51912101 3.211 NM_000966
RARG
retinoic acid receptor, gamma
chr21_+_29439768 3.188 C21orf7
chromosome 21 open reading frame 7
chr22_+_21370394 3.175 IGL@
immunoglobulin lambda locus
chr3_+_30622905 3.167 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr22_+_19699441 3.152 NM_001159554
NM_005446
P2RX6

purinergic receptor P2X, ligand-gated ion channel, 6

chr11_-_8695974 3.132 ST5
suppression of tumorigenicity 5
chr7_-_16811131 3.132 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr17_-_36996611 3.122 NM_000526
KRT14
keratin 14
chr6_+_47774247 3.109 NM_153838
GPR115
G protein-coupled receptor 115
chr10_-_31328426 3.081 NM_001143769
ZNF438
zinc finger protein 438
chr1_-_33139425 3.080 NM_033504
TMEM54
transmembrane protein 54
chr2_+_69055208 3.045 NM_019617
GKN1
gastrokine 1
chr11_-_10546654 3.039 NM_006691
LYVE1
lymphatic vessel endothelial hyaluronan receptor 1
chr6_+_12398514 3.022 NM_001168319
NM_001955
EDN1

endothelin 1

chr10_+_123862430 2.965 TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_31997738 2.929 OSBPL10
oxysterol binding protein-like 10
chr6_+_83129641 2.913 NM_006670
TPBG
trophoblast glycoprotein
chr22_+_21393107 2.905 IGLJ3
immunoglobulin lambda joining 3
chr3_+_30623376 2.884 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr11_+_101423378 2.877 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr18_+_19947314 2.873 TTC39C
tetratricopeptide repeat domain 39C
chr6_+_41712907 2.829 MDFI
MyoD family inhibitor
chr5_+_145297490 2.822 SH3RF2
SH3 domain containing ring finger 2
chr3_-_188936941 2.808 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr22_+_21464980 2.792


chr11_+_20005704 2.787 NAV2
neuron navigator 2
chr11_-_117640407 2.769 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_+_73145098 2.741 RGNEF
190 kDa guanine nucleotide exchange factor
chr18_+_18989786 2.741 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr5_-_141041982 2.730 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_24518501 2.718 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr8_+_22900863 2.690 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr5_-_141041933 2.679 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr3_-_18441763 2.655 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr11_+_101488380 2.642 NM_001195045
YAP1
Yes-associated protein 1
chr12_-_102967828 2.599 GLT8D2
glycosyltransferase 8 domain containing 2
chr10_+_24795446 2.593 KIAA1217
KIAA1217
chr14_+_95792299 2.558 NM_000710
BDKRB1
bradykinin receptor B1
chr1_+_24518398 2.503 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr20_+_44070946 2.414 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr10_+_24795465 2.412 KIAA1217
KIAA1217
chr5_+_145296313 2.406 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chrX_+_133198742 2.400 NM_001101357
CCDC160
coiled-coil domain containing 160
chr10_-_62002672 2.399 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr6_-_10527772 2.396 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr12_-_10215942 2.395 NM_001172632
NM_001172633
NM_002543
OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr9_+_123369219 2.389 NM_032552
DAB2IP
DAB2 interacting protein
chr22_+_21495273 2.388


chr9_-_116920232 2.371 NM_002160
TNC
tenascin C
chr3_+_31998269 2.356 NM_001137674
ZNF860
zinc finger protein 860
chr20_+_34206070 2.336 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr19_-_56215084 2.330 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr3_-_46582806 2.294 NM_024512
LRRC2
leucine rich repeat containing 2
chr11_-_6298284 2.290 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr15_-_72952648 2.283 NM_005697
SCAMP2
secretory carrier membrane protein 2
chr3_-_31998241 2.282 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr1_+_234372454 2.282 NM_003272
GPR137B
G protein-coupled receptor 137B
chr1_-_84237316 2.273 NM_024686
TTLL7
tubulin tyrosine ligase-like family, member 7
chr8_-_27528215 2.252 NM_001831
CLU
clusterin
chr4_-_89299034 2.249 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr2_+_33213111 2.240 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr7_+_22733290 2.231 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr11_+_35596310 2.224 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr6_-_150388292 2.188 NM_130900
RAET1L
retinoic acid early transcript 1L
chr9_-_109291866 2.185 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr6_-_119137923 2.183 NM_001178035
C6orf204
chromosome 6 open reading frame 204
chr6_+_45404031 2.169 NM_001015051
NM_001024630
RUNX2

runt-related transcription factor 2

chr4_+_40032146 2.165 NM_017581
CHRNA9
cholinergic receptor, nicotinic, alpha 9
chr17_-_36928604 2.151 NM_002275
KRT15
keratin 15
chr9_+_137694988 2.149 NM_001001676
LCN9
lipocalin 9
chr1_+_150753601 2.138 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr20_-_43410437 2.137 NM_002999
SDC4
syndecan 4
chr3_-_152517204 2.129 NM_023915
GPR87
G protein-coupled receptor 87
chr22_+_21053972 2.119


chr2_-_69033515 2.100 NM_182536
GKN2
gastrokine 2
chr12_-_105057940 2.097 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr2_+_121271336 2.091 NM_005270
GLI2
GLI family zinc finger 2
chr1_-_151280201 2.084 NM_006945
SPRR2D
small proline-rich protein 2D
chr5_+_36642424 2.080 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_220200530 2.058 NM_005070
NM_201574
SLC4A3

solute carrier family 4, anion exchanger, member 3

chr5_-_137099361 2.056 KLHL3
kelch-like 3 (Drosophila)
chr1_+_34993234 2.056 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr19_-_56164628 2.015 NM_002774
KLK6
kallikrein-related peptidase 6
chr14_+_62740878 2.014 NM_020663
RHOJ
ras homolog gene family, member J
chr8_-_27528105 2.008 CLU
clusterin
chr2_+_113591940 2.006 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr6_+_107066422 2.001 NM_001624
AIM1
absent in melanoma 1
chr5_+_36644187 1.987 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_150398327 1.983 NM_001122965
RPTN
repetin
chr18_-_72336133 1.980 NM_014643
ZNF516
zinc finger protein 516
chr9_+_676640 1.957


chr11_-_2907169 1.942 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr6_+_1556543 1.917 FOXC1
forkhead box C1
chr11_-_117640166 1.914 MPZL2
myelin protein zero-like 2
chr22_+_20899155 1.912


chr7_-_107430566 1.899 NM_002291
LAMB1
laminin, beta 1
chr11_-_119499188 1.893 TRIM29
tripartite motif containing 29
chr5_-_137099602 1.889 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr7_-_142816019 1.880 NM_005232
EPHA1
EPH receptor A1
chr11_-_76676110 1.868 NM_182833
GDPD4
glycerophosphodiester phosphodiesterase domain containing 4
chr17_+_71229110 1.818 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr18_-_26996742 1.816 NM_004948
NM_024421
DSC1

desmocollin 1

chr12_+_52733927 1.815 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_+_24522116 1.814 NM_021180
GRHL3
grainyhead-like 3 (Drosophila)
chr1_+_27591738 1.806 NM_005281
GPR3
G protein-coupled receptor 3
chr12_+_13240983 1.804 EMP1
epithelial membrane protein 1
chr17_-_37034288 1.803 NM_000422
KRT17
keratin 17
chr6_+_144040751 1.795 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_-_7923464 1.792 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr8_-_68821131 1.790 NM_020361
CPA6
carboxypeptidase A6
chr12_-_10173947 1.786 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr6_+_106653429 1.785 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_-_48661563 1.777 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr1_+_151270301 1.771 NM_003125
SPRR1B
small proline-rich protein 1B
chr14_-_22658078 1.768 NM_001805
CEBPE
CCAAT/enhancer binding protein (C/EBP), epsilon
chr2_+_233605625 1.763 NM_005383
NEU2
sialidase 2 (cytosolic sialidase)
chr15_+_99276982 1.756 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr14_-_104507862 1.749 AHNAK2
AHNAK nucleoprotein 2
chr2_+_135312655 1.746 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr12_+_13240987 1.743 EMP1
epithelial membrane protein 1
chr19_-_40684638 1.729 NM_001035516
DMKN
dermokine
chr19_+_40895669 1.726 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr17_-_36409632 1.720 NM_031959
KRTAP3-2
keratin associated protein 3-2
chr11_-_117640196 1.705 MPZL2
myelin protein zero-like 2
chr17_+_55269974 1.705


chr2_-_166359016 1.695 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_+_103898844 1.685 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr2_+_27573206 1.684 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr6_+_121798443 1.676 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr5_-_54317102 1.675 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_-_85816520 1.672 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr17_-_51155073 1.671 NM_018286
TMEM100
transmembrane protein 100
chr4_-_152366970 1.668 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr2_+_173394560 1.668 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr11_-_66898223 1.663 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr18_+_19706979 1.658 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_19842309 1.656 NM_182744
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr12_+_13240868 1.652 NM_001423
EMP1
epithelial membrane protein 1
chr19_+_43572679 1.646 NM_001039616
NM_001042522
SPRED3

sprouty-related, EVH1 domain containing 3

chr17_+_46067114 1.639 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr1_-_120112989 1.636 NM_001166107
NM_005518
HMGCS2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

chr2_+_36777336 1.628 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr8_-_125252884 1.624 C8orf78
chromosome 8 open reading frame 78
chr1_-_17179694 1.623 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr19_-_56204615 1.619 NM_012315
KLK9
kallikrein-related peptidase 9
chr1_-_221920023 1.617 NM_001143962
CAPN8
calpain 8
chr1_+_35019376 1.604 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr16_+_4546491 1.600 NM_001145011
LOC342346
hypothetical protein LOC342346
chr14_-_22515725 1.593 JUB
jub, ajuba homolog (Xenopus laevis)
chr10_+_80498782 1.593 NM_020338
ZMIZ1
zinc finger, MIZ-type containing 1
chr6_-_31756119 1.586 NM_025262
LY6G5C
lymphocyte antigen 6 complex, locus G5C
chr16_+_88515917 1.583 NM_001197181
TUBB3
tubulin, beta 3
chr7_-_93357881 1.578 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr18_+_50646616 1.577 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr3_-_71857097 1.569 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr1_+_85300580 1.569 NM_145172
WDR63
WD repeat domain 63
chr7_+_128367961 1.562 NM_001098627
IRF5
interferon regulatory factor 5
chr12_-_121224676 1.556 NM_001014336
IL31
interleukin 31
chr9_+_130942029 1.548 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.13 1.76e-07 GO:0009888 tissue development
6.08 4.48e-07 GO:0008544 epidermis development
1.76 1.20e-04 GO:0048856 anatomical structure development
2.01 3.66e-04 GO:0048513 organ development
1.74 1.10e-03 GO:0048731 system development
2.46 2.22e-03 GO:0009611 response to wounding
1.59 2.49e-03 GO:0032502 developmental process
2.39 3.03e-03 GO:0042127 regulation of cell proliferation
2.04 4.40e-03 GO:0009653 anatomical structure morphogenesis
4.37 5.42e-03 GO:0001701 in utero embryonic development
1.59 8.97e-03 GO:0007275 multicellular organismal development
2.70 1.41e-02 GO:0009887 organ morphogenesis
3.21 1.84e-02 GO:0043009 chordate embryonic development
2.52 1.91e-02 GO:0009790 embryo development
3.87 2.15e-02 GO:0048568 embryonic organ development
3.18 2.15e-02 GO:0009792 embryo development ending in birth or egg hatching
14.48 2.30e-02 GO:0030574 collagen catabolic process
3.16 2.32e-02 GO:0060429 epithelium development
22.11 2.60e-02 GO:0031581 hemidesmosome assembly
1.65 2.69e-02 GO:0048518 positive regulation of biological process
3.42 4.66e-02 GO:0006954 inflammatory response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.99 1.35e-05 GO:0005576 extracellular region
3.37 4.71e-04 GO:0031012 extracellular matrix
3.59 6.29e-04 GO:0005578 proteinaceous extracellular matrix
2.25 9.53e-04 GO:0044421 extracellular region part
1.67 1.57e-02 GO:0044459 plasma membrane part
14.31 2.74e-02 GO:0005922 connexon complex
1.42 3.29e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
2.41 2.48e-02 GO:0005198 structural molecule activity